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lcpA

LCP protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to lcpA

Browse AMR rules for lcpA

Overview

Mechanism: enhanced susceptibility to β-lactam antibiotics
Drug Classes: beta lactams|vancomycin|oxacillin
Organisms: Staphylococcus aureus
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E146K	-	enhanced susceptibility to β-lactam antibiotics	Staphylococcus aureus	beta lactams\|vancomycin\|oxacillin	Reslit	Candidate

Papers1

1

none

mutation in lcpA affects resistance to beta-lactam, vancomycin, and oxacillin

Mutation Information

Protein Change: E146K
Organisms: Staphylococcus aureus
Confers Resistance To: beta lactams|vancomycin|oxacillin
Effect on Function: enhanced susceptibility to β-lactam antibiotics
Validation Method: mutant analysis showed altered resistance profiles
Source Database: Reslit