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mcr-1.1

phosphoethanolamine transferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mcr-1.1

Browse AMR rules for mcr-1.1

Overview

Drug Classes: colistin
Organisms: Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
F265L	-	-	Escherichia coli	colistin	Reslit	Candidate

Papers1

1

In-silico Analysis of a Novel MCR-1.1 Variant on an IncX4 Plasmid Attenuating Colistin Resistance in Multidrug-Resistant Escherichia coli ST131.

PMID 40822141 · 2025

The F265L substitution in MCR-1.1 impairs lipid A modification, reducing colistin resistance.

Mutation Information

mcr-1.1: p.F265L

Protein Change: F265L
Organisms: Escherichia coli
Confers Resistance To: colistin
Validation Method: in-silico structural analysis and molecular docking
Source Database: Reslit