Home Browse Genes Browse Mutations Download Collaborators About Help

Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research

Home Browse Genes Browse Mutations Download Collaborators About Help

Browse Mutations mcr-1.1F265L

Protein ChangeF265L

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: colistin
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

In-silico Analysis of a Novel MCR-1.1 Variant on an IncX4 Plasmid Attenuating Colistin Resistance in Multidrug-Resistant Escherichia coli ST131.

PMID 40822141 · 2025

The F265L substitution in MCR-1.1 impairs lipid A modification, reducing colistin resistance.

Mutation Information

mcr-1.1: p.F265L

Protein Change: F265L
Organisms: Escherichia coli
Confers Resistance To: colistin
Validation Method: in-silico structural analysis and molecular docking
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research