mscS

mechanosensitive channel

Overview

Mechanism: reduced binding to FtsZ and compromised growth on sublethal concentrations of β-lactam antibiotics
Drug Classes: ampicillin
Organisms: Escherichia coli
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K258A	-	reduced binding to FtsZ and compromised growth on sublethal concentrations of β-lactam antibiotics	Escherichia coli	ampicillin	Reslit	Candidate
R259A	-	reduced binding to FtsZ and compromised growth on sublethal concentrations of β-lactam antibiotics	Escherichia coli	ampicillin	Reslit	Candidate

Papers1

Cytoplasmic Domain of MscS Interacts with Cell Division Protein FtsZ: A Possible Non-Channel Function of the Mechanosensitive Channel in Escherichia Coli.

PMID 25996836 · 2015

Mutations in MscS affect its interaction with FtsZ and reduce protection against ampicillin

Mutation Information

mscS: p.K258A mscS: p.R259A

Protein Change: K258A, R259A
Organisms: Escherichia coli
Confers Resistance To: ampicillin
Effect on Function: reduced binding to FtsZ and compromised growth on sublethal concentrations of β-lactam antibiotics
Validation Method: growth rate measurement in subMIC ampicillin
Source Database: Reslit

mscS

Mutations

Mutation Information

Browse AMR Genes

mscS

Mutations

Mutation Information