ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeR259A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced binding to FtsZ and compromised growth on sublethal concentrations of β-lactam antibiotics
Resistance To: ampicillin
Organisms: Escherichia coli
Papers: 1

Paper Information1

Cytoplasmic Domain of MscS Interacts with Cell Division Protein FtsZ: A Possible Non-Channel Function of the Mechanosensitive Channel in Escherichia Coli.

PMID 25996836 · 2015

Mutations in MscS affect its interaction with FtsZ and reduce protection against ampicillin

Mutation Information

mscS: p.R259A

Protein Change: R259A
Organisms: Escherichia coli
Confers Resistance To: ampicillin
Effect on Function: reduced binding to FtsZ and compromised growth on sublethal concentrations of β-lactam antibiotics
Validation Method: growth rate measurement in subMIC ampicillin
Source Database: Reslit

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