Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component regulatory system
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R83K | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
| L99P | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
| L137P | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
| V152A | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
| A168V | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
| R155H | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
| A82T | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
| A138T | - | - | - | aminoglycosides|fluoroquinolones|carbapenems | Reslit | Candidate |
Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.
Mutations in parRS lead to overexpression of mexXY and decreased OprD expression, resulting in resistance to aminoglycosides, fluoroquinolones, and carbapenems.