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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
PiuC iron-dependent oxygenase (a TonB-dependent transporter)
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S116F | - | entailing a switch from an amino acid with polar uncharged side chain (serine) to one with a hydrophobic side chain (phenylalanine), which could be involved in the binding of the siderophore | Pseudomonas aeruginosa | cefiderocol | Reslit | Candidate |
| R201H | - | - | Pseudomonas aeruginosa, Acinetobacter spp. | cefiderocol | Reslit | Candidate |
| M1V | - | - | Acinetobacter baumannii | cefiderocol | Reslit | Candidate |
Novel PiuC, PirA, and PiuA mutations leading to in vivo cefiderocol resistance progression in IMP-16- and KPC-2-producing Pseudomonas aeruginosa from a leukemic patient.
Mutation in the Fe2OG dioxygenase domain of PiuC
In vitro activity of cefiderocol against European Pseudomonas aeruginosa and Acinetobacter spp., including isolates resistant to meropenem and recent β-lactam/β-lactamase inhibitor combinations.
Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam.