ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeS116F

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: entailing a switch from an amino acid with polar uncharged side chain (serine) to one with a hydrophobic side chain (phenylalanine), which could be involved in the binding of the siderophore
Resistance To: cefiderocol
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Novel PiuC, PirA, and PiuA mutations leading to in vivo cefiderocol resistance progression in IMP-16- and KPC-2-producing Pseudomonas aeruginosa from a leukemic patient.

PMID 39873515 · 2025

Mutation in the Fe2OG dioxygenase domain of PiuC

Mutation Information

piuC: p.S116F

Protein Change: S116F
Organisms: Pseudomonas aeruginosa
Confers Resistance To: cefiderocol
Effect on Function: entailing a switch from an amino acid with polar uncharged side chain (serine) to one with a hydrophobic side chain (phenylalanine), which could be involved in the binding of the siderophore
Validation Method: experimental validation via mutation analysis and MIC testing
Source Database: Reslit

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