Browse AMR Genes

Explore antimicrobial resistance genes from the literature

rlmI

ribosomal RNA methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to rlmI

Browse AMR rules for rlmI

Overview

Mechanism: inhibits RlmI activity
Drug Classes: kanamycin
Organisms: Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K201A	-	inhibits RlmI activity	Escherichia coli	kanamycin	Reslit	Candidate

Papers1

1

c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin.

PMID 39870966 · 2025

mutation in rlmI reduces antibiotic tolerance

Mutation Information

Protein Change: K201A
Organisms: Escherichia coli
Confers Resistance To: kanamycin
Effect on Function: inhibits RlmI activity
Validation Method: streptavidin blotting assays
Source Database: Reslit