ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemutL

DNA mismatch repair protein

Protein ChangeI389*

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: truncation
Resistance To: ampicillin|oxacillin|erythromycin|trimethoprim sulfamethoxazole
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates.

PMID 18378706 · 2008

MutL truncation leads to hypermutability and increased antibiotic resistance.

Mutation Information

mutL: p.I389*

Protein Change: I389*
Organisms: Staphylococcus aureus
Confers Resistance To: ampicillin|oxacillin|erythromycin|trimethoprim sulfamethoxazole
Effect on Function: truncation
Validation Method: sequencing and mutation frequency analysis
Source Database: Reslit

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