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Browse Mutations sgmG135A

Genesgm

aminoglycoside resistance methylase

Protein ChangeG135A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: abrogated Sgm activity
Resistance To: aminoglycosides
Organisms: E. coli
Papers: 1

Paper Information1

1

Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm.

PMID 18586937 · 2008

Mutations in the SAM binding pocket and catalytic residues affect Sgm function.

Mutation Information

Protein Change: G135A
Organisms: E. coli
Confers Resistance To: aminoglycosides
Effect on Function: abrogated Sgm activity
Validation Method: in vivo and in vitro assays
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research