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Browse Mutations blaSHV-1L138P

Protein ChangeL138P

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced role in penicillin and ampicillin hydrolyzing properties
Resistance To: penicillin|ampicillin
Organisms: Escherichia coli, Klebsiella pneumoniae
Papers: 1

Paper Information1

1

Enzymatic analysis of the effect of naturally occurring Leu138Pro mutation identified in SHV β-lactamase on hydrolysis of penicillin and ampicillin.

PMID 21291571 · 2011

Mutation Information

blaSHV-1: p.L138P

Protein Change: L138P
Organisms: Escherichia coli, Klebsiella pneumoniae
Confers Resistance To: penicillin|ampicillin
Effect on Function: reduced role in penicillin and ampicillin hydrolyzing properties
Validation Method: kinetic analysis and molecular docking simulation
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research