ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemprF

a gene which contributes to membrane charge through lysinylation of PG

Protein ChangeS377L

Nucleotide ChangeT1130C

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: daptomycin
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

VraSR Two-Component Regulatory System Contributes to mprF-Mediated Decreased Susceptibility to Daptomycin in In Vivo-Selected Clinical Strains of Methicillin-Resistant Staphylococcus aureus.

PMID 21986832 · 2012

Mutations in mprF contribute to daptomycin resistance in MRSA strains.

Mutation Information

mprF: p.S377L / c.T1130C

Protein Change: S377L
Nucleotide Change: T1130C
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Validation Method: inactivation and transcomplementation of either full-length wild-type or mutated mprF in DAP-susceptible (DS) strains
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

Mutation Information

Browse AMR Mutations

Mutation Information