ResLit - Antimicrobial Resistance Gene & Mutation Database

a gene which contributes to membrane charge through lysinylation of PG

Protein ChangeI420N

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: gain-in-function, single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
Resistance To: daptomycin
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.

Staphylococcus aureus mprF with mutation conferring resistance to daptomycin; CARD accession: CARD:3003319

Genomic Insights Into Last-Line Antimicrobial Resistance in Multidrug-Resistant Staphylococcus and Vancomycin-Resistant Enterococcus.

mprF

Protein Change: I420N
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Effect on Function: bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
Source Database: Reference Gene Catalog

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