ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp2x

penicillin-binding protein 2X

Protein ChangeH394L

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: penicillin
Organisms: Streptococcus pneumoniae
Papers: 2

Paper Information2

Characterization of Pneumococcal Colonization Dynamics and Antimicrobial Resistance Using Shotgun Metagenomic Sequencing in Intensively Sampled South African Infants.

PMID 33072693 · 2020

Mutation Information

pbp2x: p.H394L

Protein Change: H394L
Organisms: Streptococcus pneumoniae
Confers Resistance To: penicillin
Validation Method: manual local alignment
Source Database: Reslit

Analysis of amino acid motif of penicillin-binding proteins 1a, 2b, and 2x in invasive Streptococcus pneumoniae nonsusceptible to penicillin isolated from pediatric patients in Casablanca, Morocco.

PMID 30170603 · 2018

Found in all PRSP and nine PISP

Mutation Information

pbp2x: p.H394L

Protein Change: H394L
Organisms: Streptococcus pneumoniae
Confers Resistance To: penicillin
Validation Method: DNA sequencing and PCR-RFLP analysis
Source Database: Reslit

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