ResLit - Antimicrobial Resistance Gene & Mutation Database

essential and highly conserved regulator of DNA replication

Protein ChangeR400H

Validation StatusCandidate

Databases

Reslit

Overview

Paper Information1

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.

dnaA mutations are associated with increased isoniazid MIC and are prevalent in supposedly susceptible strains

Protein Change: R400H
Nucleotide Change: C1200T
Confers Resistance To: isoniazid
Validation Method: competition assays, transcriptional profiling; experimental validation via growth curve and MIC assays; alamar blue reduction assays
Source Database: Reslit

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