ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneRv0678

protein

Protein ChangeS63R

Validation StatusConfirmed2+ DBs

Databases

ResFinder DatabaseReslit

Overview

Resistance To: bedaquiline, bedaquiline|clofazimine
Organisms: Mycobacterium tuberculosis
Papers: 2

Paper Information2

Variants associated with Bedaquiline (BDQ) resistance identified in Rv0678 and efflux pump genes in Mycobacterium tuberculosis isolates from BDQ naïve TB patients in Pakistan.

PMID 35209842 · 2022

variants in Rv0678 gene are associated with BDQ resistance

Mutation Information

Rv0678: p.S63R

Protein Change: S63R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: bedaquiline
Validation Method: whole genome sequencing
Source Database: Reslit

Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis.

PMID 24590481 · 2014

Mutation Information

Rv0678: p.S63R

Protein Change: S63R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: bedaquiline|clofazimine
Source Database: ResFinder Database

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