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Browse Mutations tolCI436T

GenetolC

outer membrane factor

Protein ChangeI436T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased drug concentrations inside the cell
Resistance To: doxycycline
Organisms: Francisella tularensis
Papers: 1

Paper Information1

1

Mutational Switch-Backs Can Accelerate Evolution of Francisella to a Combination of Ciprofloxacin and Doxycycline.

PMID 35615518 · 2022

Mutation Information

Protein Change: I436T
Organisms: Francisella tularensis
Confers Resistance To: doxycycline
Effect on Function: decreased drug concentrations inside the cell
Validation Method: mutant construction and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research