ResLit - Antimicrobial Resistance Gene & Mutation Database

Genemcr-1

membrane-anchored enzyme

Protein ChangeE116A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: abolished MCR-1-mediated protection of recombinant E. coli from colistin
Resistance To: colistin
Organisms: Escherichia coli
Papers: 1

Paper Information1

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment.

PMID 40693456 · 2025

Glu116 is crucial for MCR-1 activity

Mutation Information

mcr-1: p.E116A

Protein Change: E116A
Organisms: Escherichia coli
Confers Resistance To: colistin
Effect on Function: abolished MCR-1-mediated protection of recombinant E. coli from colistin
Validation Method: mutagenesis and colistin susceptibility testing
Source Database: Reslit

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