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Browse Mutations pbp2aY446N

penicillin-binding protein

Protein ChangeY446N

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: resistance to ceftaroline
Resistance To: ceftaroline
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

1

PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates.

PMID 25155594 · 2014

The Y446N mutation was found to increase ceftaroline MIC significantly.

Mutation Information

Protein Change: Y446N
Organisms: Staphylococcus aureus
Confers Resistance To: ceftaroline
Effect on Function: resistance to ceftaroline
Validation Method: in vitro binding studies and isogenic mutant strains
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research