ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneompK36

outer membrane protein

Protein ChangeQ170*

Nucleotide ChangeC508T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: premature stop codon
Resistance To: ertapenem
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

Predictability of Phenotype in Relation to Common β-Lactam Resistance Mechanisms in Escherichia coli and Klebsiella pneumoniae.

PMID 26912748 · 2016

The paper states that mutations in ompK36 or absence of OmpK36 in all isolates in which reduced susceptibility to ertapenem (MIC, >1 mg/liter) was evident.

Mutation Information

ompK36: p.Q170* / c.C508T

Protein Change: Q170*
Nucleotide Change: C508T
Organisms: Klebsiella pneumoniae
Confers Resistance To: ertapenem
Effect on Function: premature stop codon
Validation Method: sequencing
Source Database: Reslit

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