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Browse Mutations acrRM109I

GeneacrR

Protein ChangeM109I

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: single resistance variant, transcriptional regulator AcrR
Resistance To: tigecycline, multiple antibiotics
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

Mechanisms of tigecycline resistance among Klebsiella pneumoniae clinical isolates.

PMID 25182649 · 2014

Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance; CARD accession: CARD:3003373

acrR

Mutation Information

Protein Change: M109I
Organisms: Klebsiella pneumoniae
Confers Resistance To: tigecyclinemultiple antibiotics
Effect on Function: single resistance variant; transcriptional regulator AcrR
Validation Method: PCR and sequencing
Source Database: ReslitCard DatabaseReference Gene Catalog

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research