ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemprF

a gene which contributes to membrane charge through lysinylation of PG

Protein ChangeW424C

Nucleotide ChangeTGC->TGC

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: dap
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

IS256-Mediated Overexpression of the WalKR Two-Component System Regulon Contributes to Reduced Vancomycin Susceptibility in a Staphylococcus aureus Clinical Isolate.

PMID 31474962 · 2019

Mutation in mprF (Trp424Cys) contributes to daptomycin resistance

Mutation Information

mprF: p.W424C / c.TGC->TGC

Protein Change: W424C
Nucleotide Change: TGC->TGC
Organisms: Staphylococcus aureus
Confers Resistance To: dap
Validation Method: repulsion assay with cytochrome c
Source Database: Reslit

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