ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemutS

DNA mismatch repair protein

Protein ChangeR656H

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: inactivates MutS
Resistance To: ceftazidime avibactam
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection.

PMID 31530672 · 2019

R656H substitution inactivates MutS, leading to hypermutation and CZA resistance.

Mutation Information

mutS: p.R656H

Protein Change: R656H
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftazidime avibactam
Effect on Function: inactivates MutS
Validation Method: whole-genome sequencing and in vitro adaptive evolution experiments
Source Database: Reslit

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