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Browse Mutations ompK36134-135ins

outer membrane protein

Protein Change134-135ins

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: pore constriction, reducing antibiotic permeation
Resistance To: ceftazidime avibactam
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis.

PMID 38743401 · 2024

Insertion in OmpK36 causes pore constriction, reducing antibiotic permeation

Mutation Information

ompK36: p.134-135ins

Protein Change: 134-135ins
Organisms: Klebsiella pneumoniae
Confers Resistance To: ceftazidime avibactam
Effect on Function: pore constriction, reducing antibiotic permeation
Validation Method: comparative analysis of OmpK35 and OmpK36 proteins
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research