ResLit - Antimicrobial Resistance Gene & Mutation Database

penicillin-binding protein 2X

Protein ChangeA707D

Validation StatusCandidate

Databases

Reslit

Overview

Paper Information1

Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.

The wild-type PBP2x is susceptible to beta-lactam antibiotics, and the mutation A707D reduces its functionality and increases susceptibility.

Protein Change: A707D
Organisms: Streptococcus pneumoniae
Confers Resistance To: beta lactams
Effect on Function: reduces its functionality and increases susceptibility
Validation Method: mutant strain analysis, fluorescence microscopy, Bocillin FL binding, western blot
Source Database: Reslit

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