ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemutY

DNA glycosylase

Protein ChangeG199W

Nucleotide ChangeG595T

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: fluoroquinolones|ampicillin
Organisms: Campylobacter jejuni
Papers: 1

Paper Information1

A single nucleotide change in mutY increases the emergence of antibiotic-resistant Campylobacter jejuni mutants.

PMID 26169557 · 2015

The G199W mutation in mutY abolishes its anti-mutator function, leading to increased mutation frequencies and resistance to fluoroquinolones and ampicillin.

Mutation Information

mutY: p.G199W / c.G595T

Protein Change: G199W
Nucleotide Change: G595T
Organisms: Campylobacter jejuni
Confers Resistance To: fluoroquinolones|ampicillin
Validation Method: site-specific reversion and mutation, gene knockout
Source Database: Reslit

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