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Browse Mutations mcr-3T277S

phosphoethanolamine transferase

Protein ChangeT277S

Nucleotide ChangeACC->AGC

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased MCR-3 function
Resistance To: colistin
Organisms: Escherichia coli, Aeromonas veronii, Salmonella enterica, Klebsiella pneumoniae, Citrobacter freundii
Papers: 1

Paper Information1

1

Molecular Insights into Functional Differences between mcr-3- and mcr-1-Mediated Colistin Resistance.

PMID 29987148 · 2018

Mutation Information

mcr-3: p.T277S / c.ACC->AGC

Protein Change: T277S
Nucleotide Change: ACC->AGC
Organisms: Escherichia coli, Aeromonas veronii, Salmonella enterica, Klebsiella pneumoniae, Citrobacter freundii
Confers Resistance To: colistin
Effect on Function: decreased MCR-3 function
Validation Method: MIC assay
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research