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Browse Mutations mutSH21P

GenemutS

DNA mismatch repair protein

Protein ChangeH21P

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disruption of DNA mismatch repair leading to increased mutation rate
Resistance To: colistin
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

1

Rapid and Consistent Evolution of Colistin Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa during Morbidostat Culture.

PMID 28630206 · 2017

Observed in PA77 cultures

Mutation Information

Protein Change: H21P
Organisms: Pseudomonas aeruginosa
Confers Resistance To: colistin
Effect on Function: disruption of DNA mismatch repair leading to increased mutation rate
Validation Method: whole-genome deep sequencing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research