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Browse Mutations trkHT350K

GenetrkH

Potassium transporter

Protein ChangeT350K

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreases the uptake of aminoglycoside antibiotics
Resistance To: kanamycin|tobramycin|streptomycin
Organisms: Escherichia coli, Salmonella enterica
Papers: 1

Paper Information1

1

Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations.

PMID 31058961 · 2019

trkH is a potassium ion transporter involved in aminoglycoside resistance and collateral sensitivity

Mutation Information

Protein Change: T350K
Organisms: Escherichia coli, Salmonella enterica
Confers Resistance To: kanamycin|tobramycin|streptomycin
Effect on Function: decreases the uptake of aminoglycoside antibiotics
Validation Method: genomic incorporation of specific point mutations and measurement of MIC values
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research