ResLit - Antimicrobial Resistance Gene & Mutation Database

Genecfr

rRNA methyltransferase

Protein ChangeQ148K

Nucleotide ChangeC442A

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: linezolid
Organisms: Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus sciuri, Staphylococcus simulans
Papers: 1

Paper Information1

Occurrence of cfr-Positive Linezolid-Susceptible Staphylococcus aureus and Non-aureus Staphylococcal Isolates from Pig Farms.

The Q148K mutation in Cfr is responsible for phenotypes susceptible to PhLOPS A antimicrobial agents.

Protein Change: Q148K
Nucleotide Change: C442A
Organisms: Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus sciuri, Staphylococcus simulans
Confers Resistance To: linezolid
Validation Method: plasmid constructs expressing either the mutated (cfr Q148K) or nonmutated cfr genes
Source Database: Reslit

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