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Browse Mutations mepAE287G

GenemepA

MATE family efflux pump

Protein ChangeE287G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased efflux activity
Resistance To: tigecycline
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

1

Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus.

PMID 37432114 · 2023

Mutations in the mepA gene were identified as contributing to tigecycline resistance in S. aureus.

Mutation Information

Protein Change: E287G
Organisms: Staphylococcus aureus
Confers Resistance To: tigecycline
Effect on Function: increased efflux activity
Validation Method: mutant deletion and complementation, tigecycline accumulation assay, molecular docking experiments
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research