ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemurAA

peptidoglycan synthesis enzyme

Protein ChangeA115V

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: cephalosporins
Organisms: Enterococcus faecalis
Papers: 1

Paper Information1

PASTA-kinase-mediated signaling drives accumulation of the peptidoglycan synthesis protein MurAA to promote cephalosporin resistance in Enterococcus faecalis.

PMID 37688380 · 2023

Mutations in murAA suppress phenotypes associated with impaired IreK signaling.

Mutation Information

murAA: p.A115V

Protein Change: A115V
Organisms: Enterococcus faecalis
Confers Resistance To: cephalosporins
Validation Method: Genetic suppressor selections and mutagenesis
Source Database: Reslit

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