ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneblaC

beta-lactamase

Protein ChangeI105T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: enhanced catalytic efficiency and stability
Resistance To: ampicillin
Organisms: Escherichia coli, Mycobacterium smegmatis
Papers: 1

Paper Information1

Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency.

PMID 24023821 · 2013

The I105F mutation showed a stronger resistance phenotype than I105T.

Mutation Information

blaC: p.I105T

Protein Change: I105T
Organisms: Escherichia coli, Mycobacterium smegmatis
Confers Resistance To: ampicillin
Effect on Function: enhanced catalytic efficiency and stability
Validation Method: directed evolution, MIC testing, enzyme activity assays
Source Database: Reslit

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