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Browse Mutations Rv0678R94Q

protein

Protein ChangeR94Q

Validation StatusConfirmed2+ DBs

Databases

ResFinder DatabaseReslit

Overview

Resistance To: bedaquiline|clofazimine
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Acquired resistance of Mycobacterium tuberculosis to bedaquiline.

PMID 25010492 · 2014

Mutations in Rv0678 lead to upregulation of the MmpS5-MmpL5 efflux pump, causing resistance to bedaquiline and clofazimine.

Mutation Information

Protein Change: R94Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: bedaquiline|clofazimine
Validation Method: whole genome sequencing
Source Database: ReslitResFinder Database

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research