ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemepA

MATE family efflux pump

Protein ChangeV415A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased efflux of tigecycline
Resistance To: tigecycline
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes.

PMID 29039719 · 2018

Mutation Information

mepA: p.V415A

Protein Change: V415A
Organisms: Staphylococcus aureus
Confers Resistance To: tigecycline
Effect on Function: increased efflux of tigecycline
Validation Method: genomic sequencing and expression analysis
Source Database: Reslit

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