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Browse Mutations nfxBC119T

GenenfxB

efflux pump regulator

Nucleotide ChangeC119T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: overexpression of MexCD-OprJ efflux pump
Resistance To: aminoglycosides|colistin
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

1

Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections.

PMID 29307490 · 2018

Mutations in nfxB lead to overexpression of MexCD-OprJ efflux pump, resulting in collateral sensitivity.

Mutation Information

Nucleotide Change: C119T
Organisms: Pseudomonas aeruginosa
Confers Resistance To: aminoglycosides|colistin
Effect on Function: overexpression of MexCD-OprJ efflux pump
Validation Method: competition experiment
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research