ResLit - Antimicrobial Resistance Gene & Mutation Database

a gene which contributes to membrane charge through lysinylation of PG

Protein ChangeG61V

Nucleotide ChangeG182T

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: gain-in-function, single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
Resistance To: daptomycin
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.

Staphylococcus aureus mprF with mutation conferring resistance to daptomycin; CARD accession: CARD:3003319

Prevalence and Genetic Basis of Antimicrobial Resistance in Non-aureus Staphylococci Isolated from Canadian Dairy Herds.

Residue substitutions in mprF associated with daptomycin resistance.

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