ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemutS

DNA mismatch repair protein

Protein ChangeR102W

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: amikacin|colistin
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

Emergence of the Novel Aminoglycoside Acetyltransferase Variant aac(6')-Ib-D179Y and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae Due to a Disrupting Mutation in the DNA Repair Enzyme MutS.

PMID 33443109 · 2020

nonsense mutation A307T in mutS leads to hypermutable phenotype

Mutation Information

mutS: p.R102W

Protein Change: R102W
Organisms: Klebsiella pneumoniae
Confers Resistance To: amikacin|colistin
Validation Method: whole-genome sequencing and mutant frequency analysis
Source Database: Reslit

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