ResLit - Antimicrobial Resistance Gene & Mutation Database

GenerdxA

oxygen-insensitive NADPH nitroreductase

Protein ChangeT184G

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: metronidazole
Organisms: Helicobacter pylori
Papers: 1

Paper Information1

Mutations in the Antibiotic Target Genes Related to Clarithromycin, Metronidazole and Levofloxacin Resistance in Helicobacter pylori Strains from Children in China.

PMID 32099422 · 2020

Mutations in rdxA are associated with metronidazole resistance

Helicobacter pylori rdxA mutation conferring resistance to metronidazole; CARD accession: CARD:3007055

Mutation Information

rdxA: p.T184G

Protein Change: T184G
Organisms: Helicobacter pylori
Confers Resistance To: metronidazole
Effect on Function: single resistance variant
Validation Method: PCR-based sequencing
Source Database: ReslitCard Database

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