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Browse Mutations panDK209E

GenepanD

aspartate decarboxylase

Protein ChangeK209E

Nucleotide ChangeA625G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: The mutation in the C-terminal tail of PanD causes POA resistance and prevents drug binding.
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Papers: 1

Paper Information1

1

Pyrazinamide triggers degradation of its target aspartate decarboxylase.

PMID 32245967 · 2020

Mutations in the C-terminal tail of PanD confer resistance to pyrazinamide.

Mutation Information

panD: p.K209E / c.A625G

Protein Change: K209E
Nucleotide Change: A625G
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Confers Resistance To: pyrazinamide
Effect on Function: The mutation in the C-terminal tail of PanD causes POA resistance and prevents drug binding.
Validation Method: Susceptibility testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research