ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneahpC

Protein ChangeP52L

Nucleotide ChangeCCC > CTG

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: isoniazid
Papers: 1

Paper Information1

Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen.

PMID 32829049 · 2020

Mutations in ahpC are associated with isoniazid resistance.

Mutation Information

ahpC: p.P52L / c.CCC > CTG ahpC: p.P81L / c.CCC > CTG

Protein Change: P52L, P81L
Nucleotide Change: CCC > CTG
Confers Resistance To: isoniazid
Validation Method: genotypic drug susceptibility testing (gDST) and phenotypic drug susceptibility testing (pDST)
Source Database: Reslit

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