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Browse Mutations vanSR334L

GenevanS

Protein ChangeR334L

Nucleotide ChangeG1000T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: constitutive or partly constitutive expression of the vanG operon
Resistance To: vancomycin
Organisms: Clostridioides difficile
Papers: 1

Paper Information1

1

VanG- and D-Ala-D-Ser-dependent peptidoglycan synthesis and vancomycin resistance in Clostridioides difficile.

PMID 36065735 · 2022

causes constitutive or partly constitutive expression of vanG operon

Mutation Information

vanS: p.R334L / c.G1000T

Protein Change: R334L
Nucleotide Change: G1000T
Organisms: Clostridioides difficile
Confers Resistance To: vancomycin
Effect on Function: constitutive or partly constitutive expression of the vanG operon
Validation Method: mutagenesis and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research