ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemexD

efflux pump component

Protein ChangeS133G

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: multidrug efflux RND transporter permease subunit MexD
Resistance To: ceftolozane tazobactam|ceftazidime avibactam, avibactam
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Emergence of Resistance to Novel Cephalosporin–β-Lactamase Inhibitor Combinations through the Modification of the Pseudomonas aeruginosa MexCD-OprJ Efflux Pump.

PMID 34060900 · 2021

mexD

Mutation Information

mexD: p.S133G

Protein Change: S133G
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftolozane tazobactam|ceftazidime avibactamavibactam
Effect on Function: multidrug efflux RND transporter permease subunit MexD
Validation Method: construction of mexD mutants and complementation assays with wild-type nfxB
Source Database: ReslitReference Gene Catalog

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