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Browse Mutations pbp2xL403F

penicillin-binding protein 2X

Protein ChangeL403F

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced amount of PBP2x
Resistance To: cefotaxime
Organisms: Streptococcus pneumoniae
Papers: 1

Paper Information1

1

New Insights into Beta-Lactam Resistance of Streptococcus pneumoniae: Serine Protease HtrA Degrades Altered Penicillin-Binding Protein 2x.

PMID 34442764 · 2021

Mutation Information

Protein Change: L403F
Organisms: Streptococcus pneumoniae
Confers Resistance To: cefotaxime
Effect on Function: reduced amount of PBP2x
Validation Method: Western blot analysis and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research