ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemurA

antibiotic-resistant murA transferase

Protein ChangeC115S

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene Catalog

Overview

Mechanism: single resistance variant, UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
Resistance To: fosfomycin
Organisms: Escherichia coli
Papers: 1

Paper Information1

Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzyme.

PMID 8281938 · 1993

Escherichia coli murA with mutation conferring resistance to fosfomycin; CARD accession: CARD:3003775

Mutation Information

murA: p.C115S

Protein Change: C115S
Organisms: Escherichia coli
Confers Resistance To: fosfomycin
Effect on Function: single resistance variant
Source Database: Card Database

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