ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneRv0678

protein

Protein ChangeI67S

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: clofazimine, bedaquiline
Organisms: Mycobacterium tuberculosis
Papers: 2

Paper Information2

Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany.

PMID 33903103 · 2021

Mutation Information

Rv0678: p.I67S

Protein Change: I67S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: clofazimine
Validation Method: whole-genome sequencing
Source Database: Reslit

PMID 978-92-4-008241-0

Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to bedaquiline; CARD accession: CARD:3007674

Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to clofazimine; CARD accession: CARD:3007852

Mutation Information

Rv0678: p.I67S

Protein Change: I67S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: bedaquilineclofazimine
Effect on Function: single resistance variant
Source Database: Card Database

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