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Browse Mutations ndhV246A

Genendh

NADH dehydrogenase

Protein ChangeV246A

Validation StatusEstablished

Databases

Card Database

Overview

Mechanism: single resistance variant
Resistance To: isoniazid
Organisms: Mycolicibacterium smegmatis
Papers: 1

Paper Information1

1

Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.

PMID 15673755 · 2005

Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid; CARD accession: CARD:3003778

Mutation Information

Protein Change: V246A
Organisms: Mycolicibacterium smegmatis
Confers Resistance To: isoniazid
Effect on Function: single resistance variant
Source Database: Card Database

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research