ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemprF

a gene which contributes to membrane charge through lysinylation of PG

Protein ChangeT345K

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene Catalog

Overview

Mechanism: single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
Resistance To: daptomycin
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides.

PMID 26055370 · 2015

Staphylococcus aureus mprF with mutation conferring resistance to daptomycin; CARD accession: CARD:3003319

Mutation Information

mprF: p.T345K

Protein Change: T345K
Organisms: Staphylococcus aureus
Confers Resistance To: daptomycin
Effect on Function: single resistance variant
Source Database: Card Database

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