ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp2x

penicillin-binding protein 2X

Protein ChangeM593T

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: reduced β-lactam susceptibility, single resistance variant
Resistance To: ampicillin|amoxicillin, beta lactams
Organisms: Streptococcus pyogenes
Papers: 2

Paper Information2

Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated with Reduced Susceptibility to β-Lactam Antibiotics in the United States, 2015-2021.

PMID 35969070 · 2022

mutations in PBP2x associated with reduced β-lactam susceptibility

Mutation Information

pbp2x: p.M593T

Protein Change: M593T
Organisms: Streptococcus pyogenes
Confers Resistance To: ampicillin|amoxicillin
Effect on Function: reduced β-lactam susceptibility
Validation Method: sequencing and susceptibility testing
Source Database: Reslit

Genome-Wide Transposon Mutagenesis Screens Identify Group A Streptococcus Genes Affecting Susceptibility to β-Lactam Antibiotics.

PMID 36374114 · 2022

Streptococcus pyogenes PBP2x conferring resistance to beta-lactam antibiotics; CARD accession: CARD:3007531

Mutation Information

pbp2x: p.M593T

Protein Change: M593T
Organisms: Streptococcus pyogenes
Confers Resistance To: beta lactams
Effect on Function: single resistance variant
Source Database: Card Database

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